I've realized in the last couple of years that I can live without my parents. In fact, I practically do already. I worry more about losing my relationship with my in laws. Also, it would be hell on my wife for a while. She would stay with and support me, but she does understand that our lives would irrevocably changed.
As for friends, the few I have will see it as a betrayal of their trust. Sounds twisted but they will see me as having lived a lie.
Other than that, of course I will lose the prospect of everlasting life in a paradise panda petting earth.